Bioactive compounds from the seed kernels of Xylocarpus rumphii (Kostel.) Mabb.

Abstract

The objective of this study was to search for bioactive compounds from the seed kernels of Xylocarpus rumphii (Kostel.) Mabb. The ethyl acetate crude extract of X. rumphii was purified by chromatographic techniques to afford four new limonoids, xylorumphiins A-D (3, 4, 1 and 7), along with three known limonoids namely, methyl angolensate (2), xyloccensins E (5) and K (6). The chemical structures of all isolated compounds were established on the basis of chemical and spectroscopic methods. In addition, this is the first report of the complete assignments for NMR and X-ray data of xyloccensin E (5). However, all isolated compounds showed to be inactive for both antibacterial and anticancer activity assays