Recovery and purifcation of triethlamine from mother liquor of amoxicillin trihydrate production

Abstract

The triethylamine (TEA) separation from residual mother liquor of amoxicillin trihydrate process was studied. The triethylamine could be separated from the residual mother liquor by mixing with the sodium hydroxide. The effects of distillation, the residual mother liquor concentration, the reaction temperature, the reaction time and time and the pH on triethylamine recovery were investigated. The triethylamine was separated from the water-triethylamine mixture by heating the solution to temperatures above the miscibility point(about 55oC), the triethylamine separation occurred completely at reaction time greater than 15 minutes, and the pH in the range of 9 to 13. Purification of recovered triethylamine by distillation and demoisturization were studied. 2, 6,-Lutidine was separated by distillation and NaOH, CaH2 K2CO3, BaO and molecular sieve type 4o A were used for demoisturization. When organic compounds were separated from mother liquor, the COD values of wastewater could be decreased approximately 50% to 60%