Modified chitosan to enhance mucoadhesive properties for gastrointestinal drug delivery system

Abstract

The objective of this research is to modify chitosan to enhance mucoadhesive properties of chitosan in order to apply to drug delivery system, to controlled release and increase drug efficiency. The synthetic polymers with improved mucoadhesive properties provide more chance for drug to release on to the H. pylori. In addition, this polymer is non-toxic, has high solubility and swelling, and can tolevate acid in the stomach. The modified chitosan are characterized by NMR, FT-IR and DSC. The mucoadhesive properties of modified chitosan were studied at pH 1.2 which is the same condition as in the stomach. At pH 1.2, we found that the modified chitosan has a better mucoadhesive abilities than chitosan. From these reasons, we applied this polymer to controlled release of drug in the simulated gastrointestinal system. We used amoxicillin trihydrate and sodium diclofenac as drug model. Furthermore, alginate was used as a metrix polymer for beads preparation and chitosan and modified chitosan were used to coated on beads. The coated modified chitosan beads can controlled release up to 5 hours. In summary, it can be concluded that the beads coated with modified chitosan offer a novel alternative for the effective treatment of peptic ulcer.