Effect of curcuminoids extract capsules on oxidative stress in type ii diabetes mellitus

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. Hyperglycemia accelerates generation of reactive oxygen species (ROS) contribute to increase the oxidative chemical modification of proteins, lipids, DNA and nucleic acids in various tissues, causing extensive cellular damage leading to complications of diabetes. The aim of this study was to investigate the effects of curcuminoids extract capsules on oxidative stress and antioxidant enzyme activities in type II diabetes mellitus. Two hundred diabetes mellitus patients treatment with appropriated hypoglycemic drugs were participated in this study. Patients received 2 capsules of either curcuminoids extract (250 mg) or placebo capsules 3 times a day for 6 months as a supplementation. The oxidative stress parameter and antioxidant enzymes activities were measured at 0, 3 and 6 months. The results showed that malondialdehyde (MDA) levels in plasma were decrease at 3 and 6 months when compared to baseline in both group. However, the MDA, ferric reducing ability of plasma (FRAP) and -tocopherol levels in curcuminoids and placebo groups were not significantly difference between two groups. Interestingly, the activities of superoxide dismutase (SOD) were significantly increased in curcuminoids group when compare with placebo group (p<0.05). However, catalase, total glutathione, and glutathione peroxidase were not changed. This study demonstrated that oxidative stress occurred in the plasma of diabetic patients was controllable, might be due to patients receiving oral hypoglycemic drugs for treatment. In conclusion, this study demonstrated that the supplementation with curcuminoids extract capsules may enhance the effect on cellular antioxidant defense in diabetic patients by boosting superoxide dismutase activity which is antioxidant-related defenses to scavenge ROS. Additional therapy with curcuminoids extract capsules could possibly help reduce free radical activity.