Production development of violacein from marine bacteria Pseudoalteromonas sp. using adsorbent resin

Abstract

Violacein is a violet indolealkaloid produced by several species of bacteria.Due to its multiple biological activities such as antitumor, antimicrobial and antiviral properties and need for large scale supply, effective production has been developed. However, the developmenthas been limited due to end-product inhibition of violacein.In this study, five different adsorbent resins, namely HP20, XAD4, XAD7, XAD16 and XAD1180 were evaluated for efficiency to enhance violacein production from marine bacteria Pseudoalteromonassp. RAD-5DP. Dispersion of XAD1180 enhanced the highest yield, particularly when 2% w.v-1 XAD1180 was added to medium after 16 h of cultivation. This method could produce 2-fold increment in violacein production when compared with conventional fermentation and maximum yield of violacein was up to 3.285 g.L-1.