Chemical constituents of stem extracts from Gelonium multiflorum A.Juss. and their biological activities

Abstract

The chemical investigation of the stems of Gelonium multiflorum A.Juss. for biologically active constituent had led to the isolation of four mixtures and eight compounds. Their structures have been elucidated from spectroscopic data and chemical reactions. They were a mixture of saturated long chain alcohols, a mixture of long chain carboxylic acids, a mixture of three triterpenoids (α -amyrin, bauerenol and multiflorenol), a mixture of long chain esters, stigmasterol, triterpenoid I, 3-methoxy-4-propylbenzaldehyde, 5-hydroxymethyl furfuraldehyde, scopoletin, helioscopinolide A, helioscopinolide E and helioscopinolide M. The last compound was a new compound. The biological activities tests indicated that triterpenoid I, 5-hydroxymethyl furfuraldehyde and scopoletin showed the moderate cytotoxicity against brine shrimp (Artemia salin a Linn.) with LC50 38.33, 39.28 and 13.31 μg/ml, respectively. In addition, scopoletin also showed significant antioxidant activity.