Formulation development of Butea superba extract tablets

Abstract

Medicarpin were used as active marker to quality control in formulation development of Butea superba extract tablets. The investigated 2 formulations of Butea superba extract tables were 1) Butea superba extract in 50% ethanol, tapioca starch, corn starch, Avicel® PH102, Ac-di-sol®, stearic acid and Aerosil®. 2) Butea superba extract in 95% ethanol, tapioca starch, Ac-di-sol®, stearic acid and Aerosil®. Both formulations showed a good agglomerated granules, flowablity, odour, and had excellent compressibility for tableting. The physicochemical properties of selected formulation of Butea superba extract tablets such as hardness, friability, weight variation, disintegration, dissolution, content uniformity and active ingredient content were conformed to the specification of USP29. In addition the stability study of 50% ethanol Butea superba extract tablets stored in desiccator under ambient condition for 1 year and 10 months showed that the property of tablets were unchanged especially the content of medicarpin.