Development of novel polymeric materials for biomedical applications

Abstract

The study and the synthesis of novel polymneric materials is an extremely challenging research topic, which were divided into three prospective application of biomaterials including an effectual wound dressing material, an artificial nerve and scaffold for bone regeneration. First part, an antibacterial wound dressings were successfully prepared using two technique i.e. solvent casting process and gamma radiation. The materials (copper (II) alginate and copper (II) stearate/PVP hydrogel pad) exhibited the good antibacterial activity against E.coli, S. aurous, MRSA, S. epidermidis, S. pyogenes. The materials provided excellent liquid absorption properties. WVTR information showed the ability to allow water vapor to pass through the sample and prevention of agglomeration of exudates that promoted accelerated wound healing. Both of materials can possibly be applied for use as an antibacterial wound dressing base on their low-toxicity for skin cells (fibroblasts) and excellent anti- bacterial activity. Second part, the nanofibrouse PAA tube showed the responsive to ions change in the medium which was clearly showed the cycle of shrinkage and expansion during ions exchange occurred. The rapid responsive of the Na/Ca exchange of the PAA tube was occurred when using physiological salt concentration of the human body (150 mM NaCl) as an immersion medium which can be related to ions influx of an living axon. Third part, the antioxidant scaffold was prepared from gallic acid and collagen-I scaffolds using the amine-reactive-NHS ester solution which provided excellent and stable scavenging activity depending on the usage of GA concentration. The study model of cell activities after applied stress was showed the impressively high cell growth when using GA 20 for HDFa and young MSCs and GA 40 for aged MSCs.