Polymeric Beads Encapsulated with Natural Product Extracts for Oral Care Applications

Abstract

In this research, calcium alginate polymeric beads with oral hydrating natural product extracts introduces the new oral care alternative that aims to be used for the aging society. Upon ingestion, breakage of alginate shell capsules should release natural product extracts that increase saliva production as a curing approach for xerostomia. Capsaicin extract and olive oil were selected for encapsulation since their chemical properties contribute to relieving xerostomia symptoms. The preparative method of polymeric beads from alginate and calcium lactate using cryogelation in combination with inverse gelation produced double gelation polymeric layer and became the most effective approach as it yielded monodispersed core-shell polymeric hydrogel. Preparation under low temperature condition enhanced the sphericity of beads and the contact time of bead submersion in the alginate bath increase shell thickness which strengthened mechanical property of the beads. The polymeric beads were characterized for their mechanical strength, shell thickness, aspect ratio, as well as weight.