The Correlation between Thai Cardiovascular Risk Score and the Multi-Ethnic Study of Atherosclerosis (MESA) Risk Score in Thai Populations

Abstract

Objective: The purpose of this study was to examine the relationship between the Thai cardiovascular risk score (TCVRS) and the Multi-Ethnic Study of Atherosclerosis (MESA) risk score and predictors of high CAC score in Thai adults without a history of atherosclerotic cardiovascular disease.Methods: This is a cross-sectional study assessing chest computed tomography scan patients without established atherosclerotic disease in Vajira Hospital, Thailand from July to December 2018. The TCVRS, MESA, and CAC scores were analyzed to estimate coronary heart disease risk. The predictive factors for the high CAC score were assessed by using univariate and multivariable analysis. Results: The total of 84 patients were enrolled (mean age, 55.1 years and female, 65.5%), mostly zero CAC (46.4%). The correlation of TCVRS and MESA risk score was stronger than FRS and MESA risk score by r = 0.818; p<0.001 and r = 0.747; p< 0.001, respectively. The agreements were acceptable with mean difference = -0.73, SD = 0.242 and -3.78, SD = 0.539, respectively. In multivariate analysis, diabetes mellitus (odds ratio [OR]: 28.39, 95% CI:1.92-420.09; p = 0.015) and age ≥ 60 years (OR: 38.26, 95% CI:13.76-389.49; p = 0.002) were independent risk factors to predict high CAC.Conclusion: There is a strong correlation between TCVRS and MESA risk score in Thai populations, but the MESA risk score may have a lower estimated coronary heart disease risk in Thai patients, especially in patients with multiple risk factors for coronary heart disease. Diabetes mellitus was the strongest predictor of high CAC.